BIOL 283 - Pregnancy: A KISS in Time?

Credits: 4 Prerequisite: BIOL 111 and 113. No programming experience required; all necessary skills and training are provided as a set of tutorials. Kisspeptin (KISS) is a neuropeptide that controls reproductive maturation and function. Its adequate secretion is essential for correct reproductive function and successful pregnancy. Recent experimental studies have shown that KISS may act as a central integrator for other reproductive hormones and neuropeptides. For example, KISS stimulates release of the hormone prolactin (PRL), which helps to maintain pregnancy and prepare the body for lactation. In this class ,students determine the role that KISS plays in successful pregnancy using computational modeling. Students experience the world of computational modeling in neuroendocrinology by working in teams to investigate and extend an existing model for hormonal interaction between KISS and PRL in pregnancy in rats. The model will be used to generate experimentally tested predictions. Toporikova.